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EpiOcular and HCE Applications


3-D ocular tissue constructs are suitable for materials ranging from very mild to moderate eye irritants.

Test Material Compatibility

The assay is compatible with both water soluble and insoluble formulations. Both solid and liquid test materials can be tested. Since test materials are topically applied, the test system is suitable for creams, pastes, highly viscous materials, and powders.

Alternate Endpoints

For extremely mild formulations, cytokine expression analysis may be included to further evaluate ocular irritation potential. Specialized protocols may be prepared as requested through consultation with the Study Director.


In May 2009, the US EPA launched a pilot program to investigate the use of the EpiOcular assay as part of a tiered strategy for the labeling of cleaning products with anti-microbial claims.